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Article

Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase.

Nucleic acids research - 16 Nov 2016

Topalis D, Gillemot S, Snoeck R, Andrei G

Abstract excerpt

Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is currently the target of nucleos(t)ide analogue-based therapy. Mutations in DNApol that confer resistance arose in immunocompromised patients infected with herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV), and to lesser extent in...

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Identifiers

PMID: 27694307
DOI: 10.1093/nar/gkw875
PMCID: PMC5175367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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