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Article

Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.

The Journal of biological chemistry - 11 Jul 2003

Borroto Aldo, Ruiz-Paz Soraya, de la Torre Teresa Villanueva, Borrell-Pages Maria, Merlos-Suarez Anna, Pandiella Atanasio, Blobel Carl P, Baselga Josep, Arribas Joaquin

Abstract excerpt

Protein ectodomain shedding is a specialized type of regulated proteolysis that releases the extracellular domain of transmembrane proteins. The metalloprotease disintegrin tumor necrosis factor-alpha-converting enzyme (TACE) has been convincingly shown to play a central role in ectodomain shedding, but despite its broad interest, very little is known about the mechanisms that regulate its activity. An analysis...

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PMID: 12714588
DOI: 10.1074/jbc.M301673200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.PMID 12714588Read ↗

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