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Article

The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism.

Developmental cell - 17 Jan 2012

Merrick David, Chapin Hannah, Baggs Julie E, Yu Zhiheng, Somlo Stefan, Sun Zhaoxia, Hogenesch John B, Caplan Michael J

Abstract excerpt

Mutations in Pkd1, encoding polycystin-1 (PC1), cause autosomal-dominant polycystic kidney disease (ADPKD). We show that the carboxy-terminal tail (CTT) of PC1 is released by γ-secretase-mediated cleavage and regulates the Wnt and CHOP pathways by binding the transcription factors TCF and CHOP, disrupting their interaction with the common transcriptional coactivator p300. Loss of PC1 causes increased...

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Identifiers

PMID: 22178500
DOI: 10.1016/j.devcel.2011.10.028
PMCID: PMC3264829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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