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Article

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.

The American journal of pathology - 1 Jan 2001

Dubois C M, Blanchette F, Laprise M H, Leduc R, Grondin F, Seidah N G

Abstract excerpt

Transforming growth factor (TGF)-beta1 plays an essential role in cell growth and differentiation. It is also considered as a gatekeeper of immune homeostasis with gene disruption leading to autoimmune and inflammatory diseases. TGF-beta1 is produced as an inactive precursor polypeptide that can be efficiently secreted but correct proteolytic cleavage is an essential step for its activation. Assessment of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11141505
DOI: 10.1016/s0002-9440(10)63970-3
PMCID: PMC1850265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.PMID 11141505Read ↗

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Identification of serpin determinants of specificity and selectivity for furin inhibition through studies of α1PDX (α1-protease inhibitor Portland)-serpin B8 and furin active-site loop chimeras.Semantic proximity Read ↗

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The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.Semantic proximity Read ↗

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