Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of mu heavy chain in B cell development. I. Blocked B cell maturation but complete allelic exclusion in the absence of Ig alpha/beta.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1998

Cronin F E, Jiang M, Abbas A K, Grupp S A

Abstract excerpt

There is good evidence for a signaling role played by Ig heavy chain in the developmental transition through the pre-B cell stage. We have previously described signal-capable or signal-incapable mutants of mu heavy chain in which a signaling defect is caused by failure to associate with the Ig alpha/beta heterodimer. To further characterize the role of Ig heavy chain-mediated signaling in vivo, as well as in B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Antigens, CD
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Mice, Transgenic

Share to Signal Transduction

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9647231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of mu heavy chain in B cell development. I. Blocked B cell maturation but complete allelic exclusion in the absence of Ig alpha/beta.PMID 9647231Read ↗

Early B cell development requires mu signaling.Semantic proximity Read ↗

The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion.Semantic proximity Read ↗

Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.Semantic proximity Read ↗

The role of Ig beta in precursor B cell transition and allelic exclusion.Semantic proximity Read ↗

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.Semantic proximity Read ↗

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.Semantic proximity Read ↗

Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice.Semantic proximity Read ↗

The Ig heavy chain protein but not its message controls early B cell development.Semantic proximity Read ↗

The roles of preB cell receptor in early B cell development and its signal transduction.Semantic proximity Read ↗

Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.Semantic proximity Read ↗

Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.Semantic proximity Read ↗

A critical role of lambda 5 protein in B cell development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.