Article
Role of mu heavy chain in B cell development. I. Blocked B cell maturation but complete allelic exclusion in the absence of Ig alpha/beta.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1998
Cronin F E, Jiang M, Abbas A K, Grupp S A
Abstract excerpt
There is good evidence for a signaling role played by Ig heavy chain in the developmental transition through the pre-B cell stage. We have previously described signal-capable or signal-incapable mutants of mu heavy chain in which a signaling defect is caused by failure to associate with the Ig al...
Topics
- Alleles
- Animals
- Antigens, CD
- B-Lymphocytes
- Breeding
- CD79 Antigens
- Cell Differentiation
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin mu-Chains
- Mice
- Mice, Transgenic
- Receptors, Antigen, B-Cell
- Signal Transduction
- Transgenes
- Tumor Cells, Cultured