Article
The roles of preB cell receptor in early B cell development and its signal transduction.
Immunology and cell biology - 1 Apr 1997
Karasuyama H, Nakamura T, Nagata K, Kuramochi T, Kitamura F, Kuida K
Abstract excerpt
The preB cell receptor is expressed for a short period after mu heavy chain is produced, that is, at the large preB cell stage in B cell development. The severe impairment of B cell differentiation observed in mice deficient for the preB cell receptor clearly demonstrated the importance of the pr...
Topics
- Alleles
- Animals
- B-Lymphocytes
- DNA Nucleotidyltransferases
- Enzyme Activation
- Gene Rearrangement, B-Lymphocyte
- Immunoglobulin Light Chains
- Immunoglobulin Light Chains, Surrogate
- Immunoglobulins
- Integrases
- MAP Kinase Kinase Kinases
- Membrane Glycoproteins
- Mice
- Protein Serine-Threonine Kinases
- Receptors, Antigen, B-Cell
- Recombinases
- Signal Transduction