Article
The roles of preB cell receptor in early B cell development and its signal transduction.
Immunology and cell biology - 1 Apr 1997
Karasuyama H, Nakamura T, Nagata K, Kuramochi T, Kitamura F, Kuida K
Abstract excerpt
The preB cell receptor is expressed for a short period after mu heavy chain is produced, that is, at the large preB cell stage in B cell development. The severe impairment of B cell differentiation observed in mice deficient for the preB cell receptor clearly demonstrated the importance of the preB cell receptor in B cell development. Analyses of bone marrow precursor B cells in normal and B cell-deficient mutant...
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