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Article

Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice.

Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999

Bosma G C, Chang Y, Karasuyama H, Bosma M J

Abstract excerpt

Progression of pro-B lymphocytes to the pre-B stage depends on the expression of a pre-B cell receptor (pre-BCR), consisting of an Ig mu H chain, Ig surrogate light chain, and associated signal transducing chains. Mice that are unable to express a pre-BCR show an arrest of B cell development at the pro-B stage. Such is the case for severe combined immune deficient (SCID) mice in which mu chains are not made...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Light Chain

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Source

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Identifiers

PMID: 10518557
DOI: 10.1073/pnas.96.21.11952
PMCID: PMC18393

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice.PMID 10518557Read ↗

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