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Article

Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.

The Journal of experimental medicine - 7 Jun 2004

Galler Gunther R, Mundt Cornelia, Parker Mathew, Pelanda Roberta, Mårtensson Inga-Lill, Winkler Thomas H

Abstract excerpt

Early B cell development is characterized by stepwise, ordered rearrangement of the immunoglobulin (Ig) heavy (HC) and light (LC) chain genes. Only one of the two alleles of these genes is used to produce a receptor, a phenomenon referred to as allelic exclusion. It has been suggested that pre-B cell receptor (pre-BCR) signals are responsible for down-regulation of the VDJH-recombinase machinery (Rag1, Rag2, and...

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Source

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Identifiers

PMID: 15173209
DOI: 10.1084/jem.20031523
PMCID: PMC2211789

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.PMID 15173209Read ↗

Control of the sizes and contents of precursor B cell repertoires in bone marrow.Semantic proximity Read ↗

Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.Semantic proximity Read ↗

VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.Semantic proximity Read ↗

Only VpreB1, but not VpreB2, is expressed at levels which allow normal development of B cells.Semantic proximity Read ↗

The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci.Semantic proximity Read ↗

The Ig heavy chain protein but not its message controls early B cell development.Semantic proximity Read ↗

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.Semantic proximity Read ↗

The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.Semantic proximity Read ↗

Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice.Semantic proximity Read ↗

Multiple levels of selection responsive to immunoglobulin light chain and heavy chain structures impede the development of Dmu-expressing B cells.Semantic proximity Read ↗

A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.Semantic proximity Read ↗

VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.Semantic proximity Read ↗

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