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Article

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta.

The Journal of experimental medicine - 16 Apr 2007

Waisman Ari, Kraus Manfred, Seagal Jane, Ghosh Snigdha, Melamed Doron, Song Jian, Sasaki Yoshiteru, Classen Sabine, Lutz Claudia, Brombacher Frank, Nitschke Lars, Rajewsky Klaus

Abstract excerpt

We describe a mouse strain in which B cell development relies either on the expression of membrane-bound immunoglobulin (Ig) gamma1 or mu heavy chains. Progenitor cells expressing gamma1 chains from the beginning generate a peripheral B cell compartment of normal size with all subsets, but a partial block is seen at the pro- to pre-B cell transition. Accordingly, gamma1-driven B cell development is disfavored in...

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Identifiers

PMID: 17420268
DOI: 10.1084/jem.20062024
PMCID: PMC2118546

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Source receipt: pubmed, retrieved 7 Sept 2026.

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