Article
B cell development in mice that lack one or both immunoglobulin kappa light chain genes.
The EMBO journal - 1 Mar 1993
Chen J, Trounstine M, Kurahara C, Young F, Kuo C C, Xu Y, Loring J F, Alt F W, Huszar D
Abstract excerpt
We have generated mice that lack the ability to produce immunoglobulin (Ig) kappa light chains by targeted deletion of J kappa and C kappa gene segments and the intervening sequences in mouse embryonic stem cells. In wild type mice, approximately 95% of B cells express kappa light chains and only...
Topics
- Animals
- B-Lymphocytes
- Cell Differentiation
- Cell Line
- Female
- Flow Cytometry
- Gene Deletion
- Gene Rearrangement, B-Lymphocyte
- Heterozygote
- Homozygote
- Immunoglobulin kappa-Chains
- Male