B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

Abstract excerpt

We have generated mice that lack the ability to produce immunoglobulin (Ig) kappa light chains by targeted deletion of J kappa and C kappa gene segments and the intervening sequences in mouse embryonic stem cells. In wild type mice, approximately 95% of B cells express kappa light chains and only approximately 5% express lambda light chains. Mice heterozygous for the J kappa C kappa deletion have approximately...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Differentiation
• Share to Cell Line
• Share to Gene Deletion