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Article

Conformational changes of the Tet repressor induced by tetracycline trapping.

Journal of molecular biology - 5 Jun 1998

Orth P, Cordes F, Schnappinger D, Hillen W, Saenger W, Hinrichs W

Abstract excerpt

The X-ray crystal structure analysis of inducer-free Tet repressor, TetR, at 2.4 A resolution identifies one of two openings of the tunnel-like binding site as the entrance for the inducer tetracycline-Mg2+, [Mg Tc]+. Recognition and binding of the inducer unleashes conformational changes leading to the induced state of TetR. In the first step, the C-terminal turn of alpha-helix 6 unwinds, thereby altering the...

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Identifiers

PMID: 9642048
DOI: 10.1006/jmbi.1998.1775

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