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Article

Functional insights into the mode of DNA and ligand binding of the TetR family regulator TylP from Streptomyces fradiae.

The Journal of biological chemistry - 15 Sept 2017

Ray Shamayeeta, Maitra Anwesha, Biswas Anwesha, Panjikar Santosh, Mondal Jagannath, Anand Ruchi

Abstract excerpt

Tetracycline repressors (TetRs) modulate multidrug efflux pathways in several pathogenic bacteria. In Streptomyces, they additionally regulate secondary metabolic pathways like antibiotic production. For instance, in the antibiotic producer Streptomyces fradiae, a layered network of TetRs regulates the levels of the commercially important antibiotic tylosin, with TylP occupying the top of this cascading network....

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Identifiers

PMID: 28739805
DOI: 10.1074/jbc.M117.788000
PMCID: PMC5602390

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Functional insights into the mode of DNA and ligand binding of the TetR family regulator TylP from Streptomyces fradiae.PMID 28739805Read ↗

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