Article
Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Science (New York, N.Y.) - 15 Apr 1994
Hinrichs W, Kisker C, Düvel M, Müller A, Tovar K, Hillen W, Saenger W
Abstract excerpt
The most frequently occurring resistance of Gram-negative bacteria against tetracyclines is triggered by drug recognition of the Tet repressor. This causes dissociation of the repressor-operator DNA complex and enables expression of the resistance protein TetA, which is responsible for active eff...
Topics
- Antiporters
- Bacterial Proteins
- Crystallography, X-Ray
- DNA, Bacterial
- Helix-Loop-Helix Motifs
- Hydrogen Bonding
- Magnesium
- Models, Molecular
- Mutation
- Operator Regions, Genetic
- Protein Conformation
- Protein Folding