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Article

Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.

Science (New York, N.Y.) - 15 Apr 1994

Hinrichs W, Kisker C, Düvel M, Müller A, Tovar K, Hillen W, Saenger W

Abstract excerpt

The most frequently occurring resistance of Gram-negative bacteria against tetracyclines is triggered by drug recognition of the Tet repressor. This causes dissociation of the repressor-operator DNA complex and enables expression of the resistance protein TetA, which is responsible for active efflux of tetracycline. The 2.5 angstrom resolution crystal structure of the homodimeric Tet repressor complexed with...

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Identifiers

PMID: 8153629
DOI: 10.1126/science.8153629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.PMID 8153629Read ↗

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[Genetic control of tetracycline resistance in bacteria].Semantic proximity Read ↗

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Teaching TetR to recognize a new inducer.Semantic proximity Read ↗

Isolation and characterisation of transport-defective substrate-binding mutants of the tetracycline antiporter TetA(B).Semantic proximity Read ↗

On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator.Semantic proximity Read ↗

Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor.Semantic proximity Read ↗

Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity DeterminantsSemantic proximity Read ↗

Noninducible Tet repressor mutations map from the operator binding motif to the C terminus.Semantic proximity Read ↗

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