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Article

Genetic control of peripheral TCRAV usage by representation in the preselection repertoire and MHC allele-specific overselection.

International immunology - 1 Jan 2001

Torres-Nagel N, Mehling B, LeRolle A F, Joly E, Hünig T

Abstract excerpt

TCRAV segments contribute significantly to MHC restriction as illustrated by their general preference for either the CD4 or CD8 T cell subset and additional, MHC allele-specific overselection during T cell differentiation. The 10-fold over-representation of the TCRAV8S2 (VA8S2) segment in CD8 over CD4 T cells by the RT1(f) haplotype of LEW.1F rats provides the most striking example of MHC allele-specific...

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Share to CD8-Positive T-Lymphocytes
Share to Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Major Histocompatibility Complex

Share to Rats, Inbred Lew

Share to Rats, Sprague-Dawley

Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

Identifiers

PMID: 11133835
DOI: 10.1093/intimm/13.1.63

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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