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Article

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 1998

Wright J A, Keegan K S, Herendeen D R, Bentley N J, Carr A M, Hoekstra M F, Concannon P

Abstract excerpt

In fission yeast, the rad3 gene product plays a critical role in sensing DNA structure defects and activating damage response pathways. A structural homologue of rad3 in humans (ATR) has been identified based on sequence similarity in the protein kinase domain. General information regarding ATR expression, protein kinase activity, and cellular localization is known, but its function in human cells remains...

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Source

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Identifiers

PMID: 9636169
DOI: 10.1073/pnas.95.13.7445
PMCID: PMC22645

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.PMID 9636169Read ↗

ATR signalling: more than meeting at the forkSemantic proximity Read ↗

Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival.Semantic proximity Read ↗

ATR and ATRIP: Partners in Checkpoint SignalingSemantic proximity Read ↗

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.Semantic proximity Read ↗

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.Semantic proximity Read ↗

Clinical impact of ATR checkpoint signalling failure in humans.Semantic proximity Read ↗

ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cellsSemantic proximity Read ↗

Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control.Semantic proximity Read ↗

DNA Damage Responses: Mechanisms and Roles in Human DiseaseSemantic proximity Read ↗

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis.Semantic proximity Read ↗

Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation.Semantic proximity Read ↗

Cryo-EM structure of human ATR-ATRIP complex.Semantic proximity Read ↗

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