Article
Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control.
Molecular biology of the cell - 1 Oct 1999
Chapman C R, Evans S T, Carr A M, Enoch T
Abstract excerpt
The fission yeast Rad3p checkpoint protein is a member of the phosphatidylinositol 3-kinase-related family of protein kinases, which includes human ATMp. Mutation of the ATM gene is responsible for the disease ataxia-telangiectasia. The kinase domain of Rad3p has previously been shown to be essential for function. Here, we show that although this domain is necessary, it is not sufficient, because the isolated...
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