Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.

The EMBO journal - 2 Jan 1998

Cliby W A, Roberts C J, Cimprich K A, Stringer C M, Lamb J R, Schreiber S L, Friend S H

Abstract excerpt

ATR, a phosphatidylinositol kinase-related protein homologous to ataxia telangiectasia mutated (ATM), is important for the survival of human cells following many forms of DNA damage. Expression of a kinase-inactive allele of ATR (ATRkd) in human fibroblasts causes increased sensitivity to ionizing radiation (IR), cis-platinum and methyl methanesulfonate, but only slight UV radiation sensitivity. ATRkd...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Repair

Share to DNA Replication

Share to Fibroblasts

Share to Phenotype

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 9427750
DOI: 10.1093/emboj/17.1.159
PMCID: PMC1170367

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.PMID 9427750Read ↗

Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agentsSemantic proximity Read ↗

ATR and ATRIP: Partners in Checkpoint SignalingSemantic proximity Read ↗

Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival.Semantic proximity Read ↗

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.Semantic proximity Read ↗

ATM and ATR as therapeutic targets in cancerSemantic proximity Read ↗

ATR signalling: more than meeting at the forkSemantic proximity Read ↗

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.Semantic proximity Read ↗

Novel Cellular Functions of ATR for Therapeutic Targeting: Embryogenesis to TumorigenesisSemantic proximity Read ↗

Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation.Semantic proximity Read ↗

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitorsSemantic proximity Read ↗

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stressSemantic proximity Read ↗

A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.