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Article

Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival.

Molecular cancer therapeutics - 1 Apr 2007

Wilsker Deborah, Bunz Fred

Abstract excerpt

The diverse responses of human cells to various forms of DNA damage are controlled by a complex network of signaling proteins. There has been considerable interest in the components of this signaling apparatus as potential targets for new forms of anticancer therapy. In this report, we examine the contributions of an upstream signaling molecule, the ataxia telangiectasia mutated- and Rad3-related (ATR) protein...

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Source

Identifiers

PMID: 17431119
DOI: 10.1158/1535-7163.MCT-06-0679

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival.PMID 17431119Read ↗

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Recent Advances in Synergistic Antitumor Effects Exploited from the Inhibition of Ataxia Telangiectasia and RAD3-Related Protein Kinase (ATR)Semantic proximity Read ↗

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Pharmacologic inhibition of ataxia telangiectasia and Rad3‐related (ATR) in the treatment of head and neck squamous cell carcinomaSemantic proximity Read ↗

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Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR InhibitorsSemantic proximity Read ↗

Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we standSemantic proximity Read ↗

ATM and ATR as therapeutic targets in cancerSemantic proximity Read ↗

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