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Article

Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.

Current biology : CB - 7 Oct 1999

Mishra K, Shore D

Abstract excerpt

Yku70p/Yku80p, the yeast Ku protein homologue, is a DNA end-binding heterodimer involved in non-homologous end joining. It also binds to telomeres, where it plays an important role in the maintenance of telomeric DNA structure [1] [2] [3] [4] [5]. Ku protein, together with Rap1p, a telomeric DNA (TG(1-3) repeat)-binding protein, is also required to initiate transcriptional silencing, or telomere-position effect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Identifiers

PMID: 10531008
DOI: 10.1016/s0960-9822(99)80483-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.PMID 10531008Read ↗

Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing.Semantic proximity Read ↗

The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiaeSemantic proximity Read ↗

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.Semantic proximity Read ↗

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.Semantic proximity Read ↗

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read ↗

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.Semantic proximity Read ↗

Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsSemantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

RNA recognition by the DNA end-binding Ku heterodimer.Semantic proximity Read ↗

The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequences.Semantic proximity Read ↗

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