Suppression of mismatched mutation by p53: a mechanism for guarding genomic integrity.

doi:10.1007/s00109-001-0290-6

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Article

Suppression of mismatched mutation by p53: a mechanism for guarding genomic integrity.

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2002

Ballal Kalpana, Zhang Wei, Mukhopadyay Tapas, Huang Peng

Abstract excerpt

The tumor suppressor p53 plays an important role in guarding the genomic integrity of the cells. The 3'-->5' exonuclease activity of p53 has recently been recognized as a novel biochemical function of this molecule, and has been shown to preferentially excise mismatched nucleotides from DNA and enhance the DNA replication fidelity of polymerase alpha in vitro. The present study further investigated the role of...

Topics

Base Pair Mismatch
Cell Transformation, Neoplastic
Genome, Human
Humans
Hypoxanthine Phosphoribosyltransferase
Mutation
Tumor Suppressor Protein p53

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Open in PubMed

Identifiers

PMID: 11862321
DOI: 10.1007/s00109-001-0290-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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