Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice.

doi:10.1128/JVI.71.9.7124-7127.1997

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Article

Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice.

Journal of virology - 1 Sept 1997

Picchio G R, Gulizia R J, Mosier D E

Abstract excerpt

Individuals homozygous for a 32-bp deletion (delta 32) in the CCR5 gene encoding the coreceptor for macrophage-tropic human immunodeficiency virus type 1 (HIV-1) are resistant to virus infection, and heterozygous individuals show some slowing of disease progression. The impact of the CCR5 genotyp...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA
Genotype
HIV Core Protein p24
HIV-1
Humans
Kinetics
Mice
Mice, SCID
Molecular Sequence Data
RNA, Viral
Receptors, CCR5
Receptors, Cytokine
Receptors, HIV

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