Article
The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression.
Nature medicine - 1 Mar 1997
Michael N L, Chang G, Louie L G, Mascola J R, Dondero D, Birx D L, Sheppard H W
Abstract excerpt
Cellular entry of human immunodeficiency virus type 1 (HIV-1) requires binding to both CD4 (ref, 1, 2) and to one of the chemokine receptors recently discovered to act as coreceptors. Viruses that infect T-cell lines to form syncytia (syncytium-inducing, SI) are frequently found in late-stage HIV disease and utilize the chemokine receptor CXCR-4; macrophage-tropic viruses are non-syncytium-inducing (NSI), found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.