Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immunodeficiency virus type 1 infection and in the time to conversion to SI virus variants.

doi:10.1086/314522

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Article

Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immunodeficiency virus type 1 infection and in the time to conversion to SI virus variants.

The Journal of infectious diseases - 1 Dec 1998

van Rij R P, de Roda Husman A M, Brouwer M, Goudsmit J, Coutinho R A, Schuitemaker H

Abstract excerpt

The effect of a valine to isoleucine switch in the CCR2 first transmembrane domain (CCR2 64I) on the clinical course of human immunodeficiency virus type 1 (HIV-1) infection was analyzed in relation to the presence or absence of syncytium-inducing (SI) HIV-1 variants. Compared with persons with a...

Topics

Cells, Cultured
Confidence Intervals
Disease Progression
Genetic Variation
Genotype
Giant Cells
HIV Seropositivity
HIV-1
Homosexuality, Male
Humans
Isoleucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Male

Point Mutation

Proportional Hazards Models

Receptors, CCR2

Receptors, CCR5

Receptors, Chemokine

Source

Open in PubMed

Identifiers

PMID: 9815240
DOI: 10.1086/314522

Genes

CCR2
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9815240-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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