CCR5/delta(ccr5) heterozygosity: a selective pressure for the syncytium-inducing human immunodeficiency virus type 1 phenotype. NIAID AIDS Clinical Trials Group Protocol 241 Virology Team.

doi:10.1086/515307

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Article

CCR5/delta(ccr5) heterozygosity: a selective pressure for the syncytium-inducing human immunodeficiency virus type 1 phenotype. NIAID AIDS Clinical Trials Group Protocol 241 Virology Team.

The Journal of infectious diseases - 1 Jun 1998

D'Aquila R T, Sutton L, Savara A, Hughes M D, Johnson V A

Abstract excerpt

Mechanisms underlying the delay in dominance of syncytium-inducing (SI) phenotype HIV-1 (human immunodeficiency virus type 1) in vivo are unknown. Both random mutational events and selective pressures operative only late in the disease process have been suggested to underlie the shift from CCR5 t...

Topics

Adult
Female
Genotype
Giant Cells
HIV Infections
HIV-1
Heterozygote
Humans
Male
Phenotype
Receptors, CCR5
Selection, Genetic

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