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Article

Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid.

The international journal of biochemistry & cell biology - 1 Feb 2012

Krause Kerstin, Boisnard Alexandra, Ihling Christian, Ludgate Marian, Eszlinger Markus, Krohn Knut, Sinz Andrea, Fuhrer Dagmar

Abstract excerpt

In the thyroid, cAMP controls both thyroid growth and function. Gain-of-function mutations in the thyroid-stimulating hormone receptor (TSHR) lead to constitutive cAMP formation and are a major cause of autonomous thyroid adenomas. The impact of activating TSHR mutations on the signal transduction network of the thyrocyte is not fully understood. To gain more insights into constitutive TSHR signaling, rat...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22074661
DOI: 10.1016/j.biocel.2011.10.024

Genes

TSHR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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