Phosphorylation of the v-erbA protein is required for its function as an oncogene.

doi:10.1101/gad.4.10.1663

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Article

Phosphorylation of the v-erbA protein is required for its function as an oncogene.

Genes & development - 1 Oct 1990

Glineur C, Zenke M, Beug H, Ghysdael J

Abstract excerpt

The v-erbA oncogene of avian erythroblastosis virus (AEV) encodes a ligand-independent mutated version of the chicken c-erbA alpha-encoded thyroid hormone receptor. The v-erbA gene product, a 75-kD gag/v-erbA fusion protein, is phosphorylated on Ser-16/17 of its v-erbA-encoded domain, and phosphorylation at this site is increased in vivo after activation of either the PKA or PKC signal transduction pathways. To...

Topics

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Alpharetrovirus
Amino Acid Sequence
Animals
Base Sequence
Cell Differentiation
Chick Embryo
Erythroblasts
Erythrocytes
Gene Expression Regulation, Viral
Gene Products, gag

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoquinolines

Molecular Sequence Data

Mutagenesis, Site-Directed

Oncogene Proteins v-erbA

Oncogenes

Phenotype

Phosphorylation

Source

Open in PubMed

Identifiers

PMID: 1979040
DOI: 10.1101/gad.4.10.1663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1979040-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Phosphorylation of the v-erbA protein is required for its function as an oncogene.PMID 1979040Read ↗

Association of v-ErbA with Smad4 disrupts TGF-beta signaling.Semantic proximity Read ↗

v-erbA acts on retinoic acid receptors in immature avian erythroid cells.Semantic proximity Read ↗

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.Semantic proximity Read ↗

Functional regulation of thyroid hormone receptor variant TR alpha 2 by phosphorylation.Semantic proximity Read ↗

Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.Semantic proximity Read ↗

Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function.Semantic proximity Read ↗

Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation.Semantic proximity Read ↗

Multiple mutations contribute to repression by the v-Erb A oncoprotein.Semantic proximity Read ↗

A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor.Semantic proximity Read ↗

v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.Semantic proximity Read ↗

Reverse mutational analysis reveals threonine-373 as a potentially sufficient phosphorylation site for inactivation of the retinoblastoma tumor suppressor protein (pRB).Semantic proximity Read ↗

The carbonic anhydrase II gene, a gene regulated by thyroid hormone and erythropoietin, is repressed by the v-erbA oncogene in erythrocytic cells.Semantic proximity Read ↗

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