Article
Functional regulation of thyroid hormone receptor variant TR alpha 2 by phosphorylation.
Molecular and cellular biology - 1 May 1995
Katz D, Reginato M J, Lazar M A
Abstract excerpt
The thyroid hormone (T3) receptor (TR) variant TR alpha 2 is abundant in brain but does not bind T3 because of its unique C terminus. The only known function of TR alpha 2, inhibition of TR-dependent transactivation, involves competition for T3 response elements. Paradoxically, in vitro-translated TR alpha 2 bound poorly to these sites. We report here that dephosphorylation of TR alpha 2 restored its DNA binding....
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Casein Kinase II
- Cell Line
- DNA
- DNA Primers
- Genetic Variation
- Humans
- In Vitro Techniques
- Molecular Sequence Data