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Article

Functional regulation of thyroid hormone receptor variant TR alpha 2 by phosphorylation.

Molecular and cellular biology - 1 May 1995

Katz D, Reginato M J, Lazar M A

Abstract excerpt

The thyroid hormone (T3) receptor (TR) variant TR alpha 2 is abundant in brain but does not bind T3 because of its unique C terminus. The only known function of TR alpha 2, inhibition of TR-dependent transactivation, involves competition for T3 response elements. Paradoxically, in vitro-translated TR alpha 2 bound poorly to these sites. We report here that dephosphorylation of TR alpha 2 restored its DNA binding....

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Identifiers

PMID: 7739517
DOI: 10.1128/MCB.15.5.2341
PMCID: PMC230462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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