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Article

Biological Activity of Activating Thyroid-Stimulating Hormone Receptor Mutants Depends on the Cellular Context

20 May 2003

Abstract excerpt

Activating TSH receptor (TSHR) mutations are a major cause of toxic thyroid adenoma and familial hyperthyroidism, and more than 37 such mutations have been described. Previously their functional activity had been assessed in terms of cAMP and inositol phosphate production and predominantly in transiently transfected COS-7 (monkey embryonic kidney cells), a model that does not reflect effects on thyrocyte...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Protein Kinase Regulation and GTPase Signaling
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Identifiers

PMID: 12933676
DOI: 10.1210/en.2003-0438

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