Article
Dissociation of thyrotropin receptor function and thyrotropin dependency in rat thyroid tumour cell lines derived from FRTL-5.
British journal of cancer - 1 Aug 1996
van der Kallen C J, Coes J H, van Grafhorst J P, Schuuring E M, Ossendorp F A, Thijssen J H, Blankenstein M A, de Bruin T W
Abstract excerpt
Spontaneously transformed somatic thyrocyte mutants, FRTL-5/TA and FRTL-5/TP, are thyrotropin (TSH) independent for growth and show loss of the thyroid-specific phenotype, with absent thyroglobulin and thyroid peroxidase gene expression. To investigate the role of TSH-receptor (TSH-R) activation in rat thyroid growth and function, binding of TSH and TSH-induced cAMP production were measured in intact cells under...
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