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Article

The exonuclease activity of HSV-1 UL12 is required for in vivo function.

Virology - 10 May 1998

Goldstein J N, Weller S K

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) UL12 gene encodes an alkaline pH-dependent deoxyribonuclease termed alkaline nuclease. A recombinant UL12 knockout mutant, AN-1, is severely compromised for growth, and analysis of this mutant suggests that UL12 plays a role in processing complex DNA replication intermediates (R. Martinez, R. T. Sarisky, P. C. Weber, and S. K. Weller, (1996) J. Virol. 70, 2075-2085). This...

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Identifiers

PMID: 9601512
DOI: 10.1006/viro.1998.9129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The exonuclease activity of HSV-1 UL12 is required for in vivo function.PMID 9601512Read ↗

The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.Semantic proximity Read ↗

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Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activitySemantic proximity Read ↗

The herpes simplex virus alkaline nuclease is required to maintain replication fork progressionSemantic proximity Read ↗

Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.Semantic proximity Read ↗

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