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Article

The exonuclease activity of HSV-1 UL12 is required for in vivo function.

Virology - 10 May 1998

Goldstein J N, Weller S K

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) UL12 gene encodes an alkaline pH-dependent deoxyribonuclease termed alkaline nuclease. A recombinant UL12 knockout mutant, AN-1, is severely compromised for growth, and analysis of this mutant suggests that UL12 plays a role in processing complex DNA replic...

Topics

Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
DNA Primers
Defective Viruses
Enzyme Stability
Gene Deletion
Genes, Viral
Genetic Complementation Test
Herpesvirus 1, Human
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Recombinant Proteins

Recombination, Genetic

Ribonucleases

Source

Identifiers

PMID: 9601512
DOI: 10.1006/viro.1998.9129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9601512-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The exonuclease activity of HSV-1 UL12 is required for in vivo function.PMID 9601512Read ↗

The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.Semantic proximity Read ↗

Structure-function analysis of the herpes simplex virus type 1 UL12 gene: correlation of deoxyribonuclease activity in vitro with replication function.Semantic proximity Read ↗

Herpes simplex virus 1 alkaline nuclease is required for efficient egress of capsids from the nucleus.Semantic proximity Read ↗

Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence.Semantic proximity Read ↗

The product of the UL12.5 gene of herpes simplex virus type 1 is not essential for lytic viral growth and is not specifically associated with capsids.Semantic proximity Read ↗

Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activitySemantic proximity Read ↗

The herpes simplex virus alkaline nuclease is required to maintain replication fork progressionSemantic proximity Read ↗

Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.Semantic proximity Read ↗

Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.Semantic proximity Read ↗

Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.Semantic proximity Read ↗

Functional conservations of the alkaline nuclease of herpes simplex type 1 and human cytomegalovirus.Semantic proximity Read ↗

The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth.Semantic proximity Read ↗

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