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Article

Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.

Journal of virology - 1 Apr 1996

Martinez R, Sarisky R T, Weber P C, Weller S K

Abstract excerpt

Mutations in the alkaline nuclease gene of herpes simplex type 1 (HSV-1) (nuc mutations) induce almost wild-type levels of viral DNA; however, mutant viral yields are 0.1 to 1% of wild-type yields (L. Shao, L. Rapp, and S. Weller, Virology 195:146-162, 1993; R. Martinez, L. Shao, J.C. Bronstein, P.C. Weber, and S. Weller, Virology 215:152-164, 1996). nuc mutants are defective in one or more stages of genome...

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Identifiers

PMID: 8642627
DOI: 10.1128/JVI.70.4.2075-2085.1996
PMCID: PMC190043

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