Article
Role of the nuclease activities encoded by herpes simplex virus 1 UL12 in viral replication and neurovirulence.
Journal of virology - 1 Feb 2014
Fujii Hikaru, Mugitani Michio, Koyanagi Naoto, Liu Zhuoming, Tsuda Shumpei, Arii Jun, Kato Akihisa, Kawaguchi Yasushi
Abstract excerpt
Enzyme-dead mutations in the herpes simplex virus 1 UL12 gene that abolished its endo- and exonuclease activities only slightly reduced viral replication in cell cultures. However, the UL12 null mutation significantly reduced viral replication, suggesting that a UL12 function(s) unrelated to its nuclease activities played a major role in viral replication. In contrast, the enzyme-dead mutations significantly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.