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Article

Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.

Journal of virology - 1 Dec 2010

Balasubramanian Nandakumar, Bai Ping, Buchek Gregory, Korza George, Weller Sandra K

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) alkaline nuclease, encoded by the UL12 gene, plays an important role in HSV-1 replication, as a UL12 null mutant displays a severe growth defect. The HSV-1 alkaline exonuclease UL12 interacts with the viral single-stranded DNA binding protein ICP8 and promotes strand exchange in vitro in conjunction with ICP8. We proposed that UL12 and ICP8 form a two-subunit recombinase...

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Identifiers

PMID: 20943970
DOI: 10.1128/JVI.01506-10
PMCID: PMC3004347

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ATM

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Source receipt: pubmed, retrieved 7 Sept 2026.

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