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Article

The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth.

Journal of virology - 1 Jun 1994

Gao M, Matusick-Kumar L, Hurlburt W, DiTusa S F, Newcomb W W, Brown J C, McCann P J, Deckman I, Colonno R J

Abstract excerpt

The herpes simplex virus type 1 protease and related proteins are involved in the assembly of viral capsids. The protease encoded by the UL26 gene can process itself and its substrate ICP35, encoded by the UL26.5 gene. To better understand the functions of the protease in infected cells, we have isolated a complementing cell line (BMS-MG22) and constructed and characterized a null UL26 mutant virus, m100. The...

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Identifiers

PMID: 8189508
DOI: 10.1128/JVI.68.6.3702-3712.1994
PMCID: PMC236875

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The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth.PMID 8189508Read ↗

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