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The herpes simplex virus alkaline nuclease is required to maintain replication fork progression

7 Nov 2024

Abstract excerpt

Herpes simplex virus is a large double-strand DNA virus that replicates in the nucleus of the host cell and interacts with host DNA replication and repair proteins. The viral 5' to 3' alkaline nuclease, UL12, is required for production of DNA that can be packaged into infectious virus. The UL12-deleted virus, AN-1, exhibits near wild-type levels of viral DNA replication, but the DNA cannot be packaged into...

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PMID: 39508568
DOI: 10.1128/jvi.01836-24

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