Article
Structure-function analysis of the herpes simplex virus type 1 UL12 gene: correlation of deoxyribonuclease activity in vitro with replication function.
Virology - 30 Mar 1998
Henderson J O, Ball-Goodrich L J, Parris D S
Abstract excerpt
Although the product of the UL12 gene of herpes simplex virus type 1 (HSV-1) has been shown to possess both exonuclease and endonuclease activities in vitro, and deletion of most of the gene within the viral genome results in inefficient production and maturation of infectious virions, the functi...
Topics
- Animals
- Cell Line
- Cricetinae
- Deoxyribonucleases
- Enzyme Activation
- Gene Expression Regulation, Viral
- Genes, Viral
- Herpesvirus 1, Human
- Humans
- Mutation
- Rabbits
- Structure-Activity Relationship
- Virus Replication