Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional conservations of the alkaline nuclease of herpes simplex type 1 and human cytomegalovirus.

Virology - 30 Sept 1998

Gao M, Robertson B J, McCann P J, O'Boyle D R, Weller S K, Newcomb W W, Brown J C, Weinheimer S P

Abstract excerpt

The herpes simplex virus type 1 UL12 gene product, alkaline nuclease (AN), appears to be involved in viral DNA processing and capsid egress from the nucleus (Shao, L., Rapp, L. M., and Weller, S. K., Virology 196, 146-162, 1993). Although the HSV-1 AN is not absolutely essential for viral replication in tissue culture, conservation of the AN gene in all herpesviruses suggests an important role in the life cycle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genes, Viral

Share to Genetic Complementation Test

Share to Microscopy, Electron

Share to Mutation

Share to Species Specificity

Source

Identifiers

PMID: 9791036
DOI: 10.1006/viro.1998.9344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional conservations of the alkaline nuclease of herpes simplex type 1 and human cytomegalovirus.PMID 9791036Read ↗

The exonuclease activity of HSV-1 UL12 is required for in vivo function.Semantic proximity Read ↗

Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.Semantic proximity Read ↗

Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.Semantic proximity Read ↗

The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.Semantic proximity Read ↗

Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.Semantic proximity Read ↗

Evidence that the UL84 gene product of human cytomegalovirus is essential for promoting oriLyt-dependent DNA replication and formation of replication compartments in cotransfection assaysSemantic proximity Read ↗

Open reading frames UL44, IRS1/TRS1, and UL36-38 are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA synthesisSemantic proximity Read ↗

Herpes simplex virus 1 alkaline nuclease is required for efficient egress of capsids from the nucleus.Semantic proximity Read ↗

Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replicationSemantic proximity Read ↗

Structure-function analysis of the herpes simplex virus type 1 UL12 gene: correlation of deoxyribonuclease activity in vitro with replication function.Semantic proximity Read ↗

Characterization of a baculovirus alkaline nuclease.Semantic proximity Read ↗

Four of eleven loci required for transient complementation of human cytomegalovirus DNA replication cooperate to activate expression of replication genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.