Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.

doi:10.1128/JVI.03129-13

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.

Journal of virology - 1 Mar 2014

Duguay Brett A, Saffran Holly A, Ponomarev Alina, Duley Shayla A, Eaton Heather E, Smiley James R

Abstract excerpt

UNLABELLED: Infection with herpes simplex virus type 1 (HSV-1) results in the rapid elimination of mitochondrial DNA (mtDNA) from host cells. It is known that a mitochondrial isoform of the viral alkaline nuclease (UL12) called UL12.5 triggers this process. However, very little is known about the impact of mtDNA depletion on viral replication or the biology of HSV-1 infections. These questions have been difficult...

Topics

Animals
Cell Line
Chlorocebus aethiops
DNA Replication
DNA, Mitochondrial
Deoxyribonucleases
Gene Expression
Herpesvirus 1, Human
Humans
Mutation
Protein Biosynthesis
Protein Transport
Transfection
Vero Cells
Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24371054
DOI: 10.1128/JVI.03129-13
PMCID: PMC3958086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics