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Article

Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.

Journal of virology - 1 Mar 2014

Duguay Brett A, Saffran Holly A, Ponomarev Alina, Duley Shayla A, Eaton Heather E, Smiley James R

Abstract excerpt

UNLABELLED: Infection with herpes simplex virus type 1 (HSV-1) results in the rapid elimination of mitochondrial DNA (mtDNA) from host cells. It is known that a mitochondrial isoform of the viral alkaline nuclease (UL12) called UL12.5 triggers this process. However, very little is known about the impact of mtDNA depletion on viral replication or the biology of HSV-1 infections. These questions have been difficult...

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Identifiers

PMID: 24371054
DOI: 10.1128/JVI.03129-13
PMCID: PMC3958086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.PMID 24371054Read ↗

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