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Article

Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancers

1 Jun 1998

Abstract excerpt

The PTEN/MMAC1/TEP1 gene has been isolated as a tumor suppressor gene that is altered in several types of human tumors including brain, breast, and prostate cancers. In the present study, we report PTEN/MMAC1/TEP1 alterations in human lung cancers. Intragenic homozygous deletions were detected in 6 (40%) of 15 small cell lung carcinoma (SCLC) cell lines and in 2 (8%) of 25 non-small cell lung carcinoma (NSCLC)...

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PMID: 9598803
DOI: 10.1002/(sici)1098-2264(199806)22:2<152::aid-gcc10>3.0.co;2-s

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