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Article

Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1999

Hahn M, Wieland I, Koufaki O N, Görgens H, Sobottka S B, Schackert G, Schackert H K

Abstract excerpt

The high mutation rate in advanced brain tumors, recent functional studies, and the high frequency of mutations in prostate metastases all strongly suggest that PTEN/MMAC1 alterations are involved in the formation of metastases. We searched for genetic alterations in the PTEN/MMAC1 gene in 56 consecutive brain metastases from various primary tumors by loss of heterozygosity (LOH), direct sequence analysis, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10499615

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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