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Article

Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary.

Japanese journal of cancer research : Gann - 1 Nov 1997

Sakurada A, Suzuki A, Sato M, Yamakawa H, Orikasa K, Uyeno S, Ono T, Ohuchi N, Fujimura S, Horii A

Abstract excerpt

In the present study, we searched for genetic alterations of the entire coding region of PTEN/MMAC1, a recently isolated candidate tumor suppressor gene, in 178 specimens from Japanese patients with various malignant tumors by the polymerase chain reaction-single strand conformation polymorphism...

Topics

Base Sequence
Brain Neoplasms
Breast Neoplasms
DNA, Neoplasm
Female
Genes, Tumor Suppressor
Glioblastoma
Humans
Kidney Neoplasms
Loss of Heterozygosity
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasms

Ovarian Neoplasms

Pancreatic Neoplasms

Polymorphism, Single-Stranded Conformational

Source

Open in PubMed Open full text

Identifiers

PMID: 9439675
DOI: 10.1111/j.1349-7006.1997.tb00324.x
PMCID: PMC5921310

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9439675-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary.PMID 9439675Read ↗

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Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases.Semantic proximity Read ↗

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Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.Semantic proximity Read ↗

PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.Semantic proximity Read ↗

Mutation analysis of PTEN/MMAC1 in acute myeloid leukemiaSemantic proximity Read ↗

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.Semantic proximity Read ↗

Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis.Semantic proximity Read ↗

Mutation analysis of the PTEN/MMAC1 gene in lung cancer.Semantic proximity Read ↗

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