Article
Mutation analysis of the PTEN/MMAC1 gene in lung cancer.
Oncogene - 24 Sept 1998
Forgacs E, Biesterveld E J, Sekido Y, Fong K, Muneer S, Wistuba I I, Milchgrub S, Brezinschek R, Virmani A, Gazdar A F, Minna J D
Abstract excerpt
We studied PTEN/MMAC1, a newly discovered candidate tumor suppressor gene at 10q23.3, for mutations in lung cancer. One hundred and thirty-six lung cancer cell line DNAs (66 small cell lung cancers, SCLC, 61 non-small cell lung cancers, NSCLC, four mesotheliomas, five extrapulmonary small cell ca...
Topics
- Carcinoma, Small Cell
- Chromosome Mapping
- DNA Mutational Analysis
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Humans
- Loss of Heterozygosity
- Lung Neoplasms
- Mutation
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Point Mutation
- Polymorphism, Single-Stranded Conformational