Article
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
Oncogene - 30 Jul 1998
Yokomizo A, Tindall D J, Drabkin H, Gemmill R, Franklin W, Yang P, Sugio K, Smith D I, Liu W
Abstract excerpt
A putative tumor suppressor, PTEN/MMAC1 gene at 10q23 was recently identified and found to be mutated in many different human tumors. To determine the role of the PTEN/MMAC1 gene in lung cancer, we screened 34 small cell lung cancer (SCLC) cell lines, 10 SCLC tumors, 13 non-small cell lung cancer...
Topics
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Exons
- Genes, Tumor Suppressor
- Humans
- Lung Neoplasms
- Mutation
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Protein Tyrosine Phosphatases
- RNA Splicing
- Tumor Cells, Cultured
- Tumor Suppressor Proteins