Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation.

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Article

Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1998

Kato J, Motoyama N, Taniuchi I, Takeshita H, Toyoda M, Masuda K, Watanabe T

Abstract excerpt

Lyn kinase-deficient (lyn-/-) mice show several abnormalities such as reduced numbers of circulating B cells, hyper-IgM, and low proliferative responses induced by CD40 ligand. Lyn-/- mice also develop splenomegaly, produce autoreactive Abs with age, and finally develop glomerulonephritis. Anothe...

Topics

Amino Acid Sequence
Animals
Antibody Affinity
Base Sequence
CD40 Antigens
CD40 Ligand
Germinal Center
Immunization
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Membrane Glycoproteins
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutation
src-Family Kinases

Source

Open in PubMed

Identifiers

PMID: 9590225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9590225-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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