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Article

Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1998

Kato J, Motoyama N, Taniuchi I, Takeshita H, Toyoda M, Masuda K, Watanabe T

Abstract excerpt

Lyn kinase-deficient (lyn-/-) mice show several abnormalities such as reduced numbers of circulating B cells, hyper-IgM, and low proliferative responses induced by CD40 ligand. Lyn-/- mice also develop splenomegaly, produce autoreactive Abs with age, and finally develop glomerulonephritis. Another abnormality observed in lyn-/- mice is that their disability to form germinal centers (GCs). It has been considered...

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Identifiers

PMID: 9590225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation.PMID 9590225Read ↗

A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.Semantic proximity Read ↗

B cells from aged mice do not have intrinsic defects in affinity maturationSemantic proximity Read ↗

Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.Semantic proximity Read ↗

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.Semantic proximity Read ↗

Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin.Semantic proximity Read ↗

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.Semantic proximity Read ↗

A dominant function of LynB kinase in preventing autoimmunitySemantic proximity Read ↗

Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal CentersSemantic proximity Read ↗

Lymph node germinal centers form in the absence of follicular dendritic cell networks.Semantic proximity Read ↗

Ig VH hypermutation is absent in the germinal centers of aged mice.Semantic proximity Read ↗

Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background.Semantic proximity Read ↗

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient miceSemantic proximity Read ↗

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