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Article

Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background.

Journal of autoimmunity - 1 Dec 2012

Lau Maverick, Tsantikos Evelyn, Maxwell Mhairi J, Tarlinton David M, Anderson Gary P, Hibbs Margaret L

Abstract excerpt

Atopy and autoimmunity are usually considered opposed immunological manifestations. Lyn(-/-) mice develop lupus-like autoimmune disease yet have coexistent intrinsic allergic traits and are prone to severe, persistent asthma induced exogenously. Recently it has been proposed that the Th2 environment and IgE auto-Abs promotes autoimmune disease in Lyn(-/-) mice. To examine this apparent contradiction, we derived...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22867713
DOI: 10.1016/j.jaut.2012.06.003

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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