Article
p21WAF1 mutation is not a predominant alteration in pediatric bone tumors.
Pediatric research - 1 Mar 1998
Patiño-García A, Sotillo-Piñeiro E, Sierrasesúmaga-Ariznabarreta L
Abstract excerpt
The molecular events leading to the development of pediatric bone tumors are not clear to date, but abnormal cell cycle progression has been reported in a wide variety of human tumors due to the alteration of several tumor suppressor genes. We have analyzed 55 bone sarcoma samples from pediatric...
Topics
- Base Sequence
- Bone Neoplasms
- Cell Cycle
- Child
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Primers
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Humans
- Mutation
- Osteosarcoma
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sarcoma, Ewing