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Article

Genetic and Epigenetic Alterations of the Cell Cycle Regulators and Tumor Suppressor Genes in Pediatric Osteosarcomas

30 Apr 2003

Abstract excerpt

PURPOSE: To analyze the genetic and epigenetic alterations affecting the RB1, TP53, p16INK4, and p21WAF1 tumor suppressor genes, loss of heterozygosity (LOH) at 3q and 18q, and the clinical variables of a series of Spanish children with osteosarcoma. These genetic changes were tested for an association with prognosis. METHODS: Peripheral blood samples and clinical data were available from 76 patients with...

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PMID: 12759621
DOI: 10.1097/00043426-200305000-00003

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Genetic and Epigenetic Alterations of the Cell Cycle Regulators and Tumor Suppressor Genes in Pediatric OsteosarcomasPMID 12759621Read ↗

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