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Article

Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 1998

Kanemoto N, Hishigaki H, Miyakita A, Oga K, Okuno S, Tsuji A, Takagi T, Takahashi E, Nakamura Y, Watanabe T K

Abstract excerpt

To elucidate the genetic factors underlying non-insulin-dependent diabetes mellitus (NIDDM), we performed genome-wide quantitative trait locus (QTL) analysis, using the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF rat is an excellent animal model of NIDDM because the features of the disease closely resemble human NIDDM. Genetic dissection with two kinds of F2 intercross progeny, from matings between...

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PMID: 9585427
DOI: 10.1007/s003359900789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus.PMID 9585427Read ↗

Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.Semantic proximity Read ↗

Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.Semantic proximity Read ↗

Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method.Semantic proximity Read ↗

Fine mapping of the hyperglycemic and obesity QTL by congenic strains suggests multiple loci on rat chromosome 14.Semantic proximity Read ↗

Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats.Semantic proximity Read ↗

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.Semantic proximity Read ↗

X-linked locus is responsible for non-insulin-dependent diabetes mellitus in the OLETF rat.Semantic proximity Read ↗

Genetic analysis of non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.Semantic proximity Read ↗

Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.Semantic proximity Read ↗

Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.Semantic proximity Read ↗

Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF.Semantic proximity Read ↗

OLETF allele of hyperglycemic QTL Nidd3/of is dominant.Semantic proximity Read ↗

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