Article
Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.
Experimental animals - 1 Apr 2001
Yamada T, Miyake T, Sugiura K, Narita A, Wei K, Wei S, Moralejo D H, Ogino T, Gaillard C, Sasaki Y, Matsumoto K
Abstract excerpt
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type non-insulin-dependent diabetes mellitus (NIDDM) in humans. Our present investigation was designed to identify epistatic interactions influencing NIDDM by performing least squares analysis of variance of all pairs of informative markers in 160 F2 progenies bred from an intercross of OLETF and Fischer-344 rats. We identified four...
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