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Article

Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF.

Genomics - 15 Nov 2000

Ogino T, Wei S, Wei K, Moralejo D H, Kose H, Mizuno A, Shima K, Sasaki Y, Yamada T, Matsumoto K

Abstract excerpt

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes in human. Obesity is essential for the onset of type 2 diabetes in this rat. Our present investigation was designed to identify quantitative trait loci (QTLs) contributing to obesity by performing a who...

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Source

Identifiers

PMID: 11087657
DOI: 10.1006/geno.2000.6349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11087657-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF.PMID 11087657Read ↗

Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.Semantic proximity Read ↗

Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats.Semantic proximity Read ↗

Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.Semantic proximity Read ↗

Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.Semantic proximity Read ↗

Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method.Semantic proximity Read ↗

Fine mapping of the hyperglycemic and obesity QTL by congenic strains suggests multiple loci on rat chromosome 14.Semantic proximity Read ↗

X-linked locus is responsible for non-insulin-dependent diabetes mellitus in the OLETF rat.Semantic proximity Read ↗

Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat.Semantic proximity Read ↗

Identification of genes specifically expressed in the accumulated visceral adipose tissue of OLETF ratsSemantic proximity Read ↗

A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats.Semantic proximity Read ↗

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.Semantic proximity Read ↗

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